ISUOG consensus statement on the impact of non-invasive prenatal testing (NIPT) on prenatal ultrasound practice.

The emergence of effective cell-free fetal DNA-based techniques to screen for trisomy 21 and other aneuploidies has greatly expanded the range of prenatal tests available over the last few years. Non-invasive prenatal testing (NIPT) is rapidly being incorporated into prenatal care, thus changing the traditional approach to prenatal screening and diagnosis. However, although NIPT techniques are highly efficient, their role and performance must be considered alongside and combined with other screening modalities. The role of prenatal ultrasound in particular needs to be reassessed as NIPT becomes more widely available. It is important to emphasize that the main goal of prenatal screening is to provide accurate information that will facilitate the delivery of optimized antenatal care, with the best possible outcome for both mother and fetus. Women should be informed about prenatal screening performance by appropriately trained health professionals, allowing them to make an informed decision. It is the parent’s choice to undergo such procedures, and their wishes should be determined and respected. The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) has compiled the following Consensus Statement, which will be updated on a regular basis.